Miller Group


Welcome to the Miller research group at Keele University

We are a group of organic chemists focused on carbohydrate synthesis. We are interested in making tools for glycobiology, new glycomaterials and carbohydrates in medicinal chemistry. Please browse the site using the links above and follow us on Twitter @millerlabkeele


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We are recruiting for 2020!


Fully funded 4 yr PhD studentship in Chemoenzymatic Carbohydrate Synthesis

We are seeking a motivated candidate for a BBSRC funded PhD research project entitled: 'Chemoenzymatic approaches to explore polysaccharide structure-property relationships.' A collaborative project with Rob Field's lab at the Manchester Institute of Biotechnology and Unilever. For full details of the position please email GJM (attach a CV) for informal inquiries or see the advert here.


Group News

May 2020 - Laura and Eleni's preprint uncovering the first sugar nucleotide inhibitor of the GDP-mannose dehydrogenase from Pseudomonas aeruginosa is out on ChemRxiv, see here.


Apr 2020 - Dr Meenakshi Singh will be joining us an EPSRC-SFI funded PDRA to work on fluorescent labelling and oligosaccharide synthesis. Meenakshi joins from Prof Lugi Lay's group in Milan. Welcome Meenakshi!

Apr 2020
- Mieke and Caecilie's article covering recent advances in the chemical synthesis of nucleoside analogues for anticancer research has been accepted in Molecules.

Mar 2020 - A second collaborative preprint with Mark Skidmore, Scott Guimond and Marcelo Lima at Keele on heparin preventing SARS-CoV-2 invasion is out now on bioRxiv.

Apr 2020
- GJM has been awarded a UKRI Future Leaders Fellowship. See press release here.

Mar 2020 - A collaborative preprint with Mark Skidmore, Scott Guimond and Marcelo Lima at Keele on heparin binding to the CoV2 surface is out now on bioRxiv.

Mar 2020 - Laura has passed her PhD viva with minor corrections. Huge congratulations and thanks to Prof. Sabine Flitsch (MIB) and Dr Matthew O'Brien (Keele) for examining.
Feb 2020 - Eleni has also passed her PhD viva with minor corrections. Huge congratulations and thanks to Prof. Stefan Oscarson (UCD) and Dr Mike Edwards (Keele) for examining.
Viva celebrations
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Jan 2019 - A collaborative paper with Dr Mark Skidmore and colleagues at Keele using chondroitin sulfate extracts to inhibit BACE1 is out now in Neural Regeneration Research.

Dec 2019 - Laura, Eleni and Hannah's paper exploring anomeric glycosylation of phosphoric acid is out now in Carbohydrate Research.

Dec 2019 - Eleni and Laura have both submitted their PhD theses! Congratulations!

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Oct 2019 - Lloyd Murphy and Alex Compton have started as MChem researchers working on nucleoside analogue projects, welcome both!

Oct 2019
- Alice Wahart has joined the group as a PhD student working on polysaccharide building blocks in collaboration with Croda, welcome Alice!

Oct 2019
- Eleni's paper on the synthesis of hydroxamate-modified alginate disaccharides is out now in a special web-themed issue on Glycosylation in Organic and Biomolecular Chemistry.

Sept 2019
- Jack Porter has joined the group as a PhD student working on polysaccharide building blocks in collaboration with Croda, welcome Jack!

Sept 2019
- Laura's paper on the synthesis of the sugar nucleotide GDP-ManA is out now in Carbohydrate Research.

June 2019
- Our paper using a chemoenzymatic approach towards sugar-nucleotide structure-function tools for a bacterial dehydrogenase is out now in Organic Letters.

June 2019 - Keele end of year ball 2019

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March 2019
- Celebrating International Women's Day 2019 (with a hostage!)

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Sept 20198- Eleni's paper using flow synthesis to access pharmaceutically relevant heterocyles is out now in Tetrahedron. A collaborative project with Dr Matthew O'Brien at Keele.