Miller Group

Publications

37. Exploring a glycosylation methodology for the synthesis of hydroxamate-modified alginate building blocks
E. Dimitriou and G. J. Miller,
Org. Biomol. Chem, 2019, accepted.
Part of a web-themed special issue - Glycosylation: New methodologies for oligosaccharide and glycoconjugate synthesis and their applications

36.
Inhibition of BACE1, the β-secretase implicated in Alzheimer’s Disease, by a chondroitin sulfate extract from Sardina pilchardus
C. J. Mycroft-West, A. J. Devlin, C. L. Cooper, P. Procter, G. J. Miller, D. G. Fernig, M. Guerrini, S. E. Guimond, M. A. de Lima, E. A. Yates and M. Skidmore, Neur. Regen. Res., 2019, accepted.

35.
Synthesis of 1’-(4’-thio-β-D-ribofuranosyl) uracil
M. Guinan, D. Lynch, M. Smith and G. J. Miller, Carbohydrate Chemistry: Proven Synthetic Methods, 
52019, CRC Press, in production

34.
An alternative synthesis of 3-Azidopropyl 2,4,6-tri-O-benzyl-β-D-galactopyranosyl-(14)-2,3,6-tri-O-benzyl-β-D-glucopyranoside
M. Reihill, A. Ní Cheallaigh, C. M. M. Benckendorff and S. Oscarson,
Carbohydrate Chemistry: Proven Synthetic Methods52019, CRC Press, in production
Procedure verified by C. M. M. Benckendorff in GJM lab.

33. Synthesis of dibenzyl 2,3,4,6-tetra-O-benzyl-α-D-mannopyranosyl phosphate 
S Ahmadipour, B. Riedl and G. J. Miller, Carbohydrate Chemistry: Proven Synthetic Methods52019, CRC Press, in production

32.
Chemical and enzymatic synthesis of the alginate sugar nucleotide building block: GDP mannuronic acid
L. Beswick, S. Ahmadipour, J. P. Dolan,, M. Rejzek, R. A. Field and G. J. Miller, 
Carbohydr. Res., 2019, 485, 107819

31. Synthesis of allyl-α-(12)-linked mannobioside from a common 1,2-orthoacetate precursor
N, Trattnig, A. NÍ Cheallaigh and P. Kosma,
Carbohydrate Chemistry: Proven Synthetic Methods52019, CRC Press, in production
Procedure verified by A. NÍ Cheallaigh in GJM lab.


30. 6R/S-deutero-α-D-mannopyranoside 1-phosphate 
S. Ahmadipour and G. J. Miller, Molbank, 20192019, M1068
Part of a Special Issue:
Organic Synthesis of Carbohydrates

29.
Chemoenzymatic synthesis of C6-modified sugar-nucleotides to probe the GDP mannose dehydrogenase from Pseudomonas aeruginosa
S. Ahmadipour, G. Pergolizzi, M. Rejzek, R. A. Field and G. J. Miller, 
Org. Lett., 2019, 21, 4415-4419

28.
Gas-liquid flow hydrogenation of nitroarenes: efficient access to a pharmaceutically relevant pyrrolobenzo[1,4]diazepine scaffold 
E. Dimitriou, R. H. Jones, R. G. Pritchard, G. J. Miller* and M. O’Brien*, 
Tetrahedron, 2018, 74, 6795-6803.

27. Recent advances in the enzymatic synthesis of sugar-nucleotides using nucleotidylyltransferases and glycosyltransferases 
S. Ahmadipour, L. Beswick and G. J. Miller, 
Carbohydr. Res., 2018469, 38-47.

26. Synthesis of 1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-D-glucopyranose using the diazo-transfer reagent imidazole-1-sulfonyl azide hydrogen sulfate
G. T. Potter, G. C. Jayson, J. M. Gardiner, L. Guazelli and G. J. Miller, 
J. Carb. Chem.201837, 178.

25. Recent advances in the chemical synthesis of sugar-nucleotides 
S. Ahmadipour and G. J. Miller, 
Carbohydr. Res., 2017451, 95-109 (part of a virtual special issue: Eurocarb 2017).

24. Synthesis of 1,3,4,6-tetra-O-acetyl-2-azido-2-deoxy-D-glucopyranose using the diazo-transfer reagent imidazole-1-sulfonyl azide hydrogen sulfate 
G. T. Potter, L. Guazelli, G. C. Jayson, G. J. Miller, J. M. Gardiner,
Carbohydrate Chemistry: Proven Synthetic Methods4, ch.18, 2017, 151-156, CRC Press.

23. 1,2,3,4-Tetra-O-Acetyl-D-mannuronic acid 
L. Beswick and G. J. Miller, Molbank, 20172017, M947.

22. Synthetic Site-Selectively Mono-6-O-Sulfated Heparan Sulfate Dodecasaccharide Shows Anti-Angiogenic Properties In Vitro and Sensitizes Tumors to Cisplatin In Vivo 
E. Avizienyte, C. L. Cole, G. Rushton, G. J. Miller, A. Bugatti, M. Presta, J. M. Gardiner and G. C. Jayson, 
PLoS ONE, 201611, e0159739.

21. Preparation of Methyl 1,2,3,4-tetra-O-acetyl-β-D-glucopyranuronate 
A. Ní Cheallaigh, G. T. Potter, J. M. Gardiner and G. J. Miller, 
Org. Synth., 201693, 200-209.

20. An Updated Synthesis of the Diazo-Transfer Reagent Imidazole-1-sulfonyl Azide Hydrogen Sulfate 
G.T. Potter, G. C. Jayson, G. J. Miller and J. M. Gardiner,
 J. Org. Chem., 201681, 3443–3446.

19. Amyl nitrite-mediated conversion of aromatic and heteroaromatic primary amides to carboxylic acids G. T. Potter, G. C. Jayson, G. J. Miller, J. M. Gardiner, Tetrahedr.. Lett., 201556, 5153-5156.

18. Modular Synthesis of Heparin-Related Tetra-, Hexa- and Octasaccharides with Differential O-6 Protections: Programming for Regiodefined 6-O-Modifications M. Barath, S. U. Hansen, C. E. Dalton, G. C. Jayson, G. J. Miller, J. M. Gardiner, Molecules, 201520, 6167-6180 (part of a special issue: Glycosaminoglycans and their Mimetics).

17. Synthesis of L‐Iduronic Acid Derivatives via [3.2.1] and [2.2.2] L‐Iduronic Lactones from Bulk Glucose-Derived Cyanohydrin Hydrolysis: A Reversible Conformationally Switched Superdisarmed/ Rearmed Lactone Route to Heparin Disaccharides  S. U. Hansen, C. E. Dalton, M. Baráth, G. Kwan, J. Raftery, G. C. Jayson, G. J. Miller, J. M. Gardiner, J. Org. Chem., 201580, 3777-3789.

16. A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides  G. J. Miller, K. R. Broberg, C. Rudd, M. R. Helliwell, G. C. Jayson, J. M. Gardiner, Org. Biomol. Chem.2015, 13, 11208-11219.

15. Making the longest sugars: a chemical synthesis of heparin-related [4]n oligosaccharides from 16-mer to 40-mer  S. U. Hansen*, G. J. Miller*, M. J. Cliff, G. C. Jayson, J. M. Gardiner, Chem. Sci.20156, 6158-6164 (Referee recommended Hot Article July 2015)

14. Development of synthetic heparan sulfate oligosaccharides as anti-angiogenic agents G. C. Jayson, S. U. Hansen, G. J. Miller, C. L. Cole, G. Rushton, J. M. Gardiner, E. Avizienyte, Cancer Res., 201575, 1375.

13. Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology  G. C. Jayson, S. U. Hansen, G. J. Miller, C. L. Cole, G. Rushton, E. Avizienyte, J. M. Gardiner, Chem. Commun., 201551, 13836-13849.

12. The development of anti-angiogenic heparan sulfate oligosaccharides
G. C. Jayson, G. J. Miller, S. U. Hansen, M. Baráth, J. M .Gardiner, E. Avizienyte, 
Biochem. Soc. Trans.201442, 1596-1600.

11. Synthesis of a heparin-related GlcN–IdoA sulfation-site variable disaccharide library and analysis by Raman and ROA spectroscopy
G. J. Miller, S. U. Hansen, M. Baráth, C. Johannessen, E. Blanch, G. C. Jayson, J. M .Gardiner, 
Carbohydr. Res., 2014400, 44-53.

10. Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesiopn  N. Takemoto, T. Suehara, H. Frisco, S.-I. Sato, T. Sezaki, K. Kusamori, Y. Kawazoe, S. M. Park, S. Yamazoe, Y. Mizuhata, R. Inoue, G. J. Miller, S. U. Hansen, G. C. Jayson, J. M. Gardiner, T. Kanaya, N. Tokitoh, K. Ueda, Y. Takakura, N. Kioka, M. Nishikawa, M. Uesugi, J. Am. Chem. Soc.2013135, 11032-11039.  

9. Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies S. U. Hansen*, G. J. Miller*, G. Rushton, E. Avizienyte, C. Cole, G. C. Jayson, J. M. Gardiner, Nature Commun.20134, 2016.

8. Efficient chemical synthesis of heparin-like octa-, deca- and dodecasaccharides and inhibition of FGF2- and VEGF165-mediated endothelial cell functions  G. J. Miller, S. U. Hansen, M. Baráth, G. Rushton, C. Cole, E. Avizienyte, G. C. Jayson, J. M. Gardiner, Chem. Sci., 20134, 3218-3222.

7. First Gram-Scale Synthesis of a Heparin-Related Dodecasaccharide 
S. U. Hansen, G. J. Miller, G. C. Jayson, J. M. Gardiner, 
Org. Lett.201315, 88-91 (C&EN News Highlight Article: 2012, 90, 17).                               

6. Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice  D. C. Pryde, L. H. Jones, D. P. Gervais, D. R. Stead, D. C. Blakemore, M. D. Selby, A. D. Brown, J. W. Coe, M. Badland, D. M. Beal, R. Glen, Y. Wharton, G. J. Miller, P. White, N. Zhang, M. Benoit, K. Robertson, J. R. Merson, H. L. Davis, M. J. McCluskie, PLoS ONE, 201310, e76557.

5. Synthesis and Scalable Conversion of L‐Iduronamides to Heparin- Related Di- and Tetrasaccharides 
S. U. Hansen*, G. J. Miller*, M. Baráth, K. R. Broberg, E. Avizienyte, G. C. Jayson, J. M. Gardiner, 
J. Org. Chem.201277, 7823-7843.

4. A synthesis of C-glycosidic multivalent mannosides suitable for divergent functionalized conjugation
G. J. Miller, J. M. Gardiner, 
Tetrahedr. Lett.201152, 3216–3218.

3. Adaptable Synthesis of C-Glycosidic Multivalent Carbohydrates and Succinamide-Linked Derivatization 
G. J. Miller, J. M. Gardiner, 
Org. Lett.201012, 5262-5265. 

2. Synthesis of the Marine Glycolipid Dioctadecanoyl Discoside 
G. J. Florence, T. Aslam, G. J. Miller, G. D. Milne, S. J. Conway, 
Synlett., 200919, 3099-3102.
         
1. Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives
S. J. Conway, G. J. Miller, 
Nat. Prod. Rep., 200724, 687-707.