Miller Group

Aisling Ní Cheallaigh undertook a BSc. In Medicinal Chemistry and Chemical Biology at University College Dublin (UCD) and graduated with first class honours. Upon receipt of a prestigious IRCSET scholarship she began her postgraduate studies through which she obtained a Ph.D. in Synthetic Carbohydrate Chemistry with Prof Stefan Oscarson. Following completion of her PhD she moved to the University of Manchester to the labs of Prof Nigel Scrutton and Dr John Gardiner and carried out a 2 year PDRA position in organic synthesis of monoterpenoid derivatives for use in a synthetic biology programme. She then spent a year in industry as a Senior Scientist in Chemical Development at AstraZeneca. She has recently returned to academia to a PDRA position with Prof. Stefan Oscarson at University College Dublin working on the synthesis of human and bacterial oligosaccharides.

Research Group

Post-Doctoral Researchers

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Dr Aisling Ní Cheallaigh

Aisling undertook a BSc. In Medicinal Chemistry and Chemical Biology at University College Dublin (UCD) and graduated with first class honours. Upon receipt of a prestigious IRCSET scholarship she began her postgraduate studies through which she obtained a Ph.D. in Synthetic Carbohydrate Chemistry with Prof Stefan Oscarson. Following completion of her PhD she moved to the University of Manchester to the labs of Prof Nigel Scrutton and Dr John Gardiner and carried out a 2 year PDRA position in organic synthesis of monoterpenoid derivatives for use in a synthetic biology programme. She then spent a year in industry as a Senior Scientist in Chemical Development at AstraZeneca. She has recently returned to academia to a PDRA position with Prof. Stefan Oscarson at University College Dublin working on the synthesis of human and bacterial oligosaccharides.



PhD students

3rd Year

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Laura Beswick

Laura was born in Stoke-on-Trent, Staffordshire and graduated from Keele University in July 2016 with a BSc in Medicinal Chemistry with Forensic Science. Her final year project involved the design and synthesis of novel 1-oxide-2-phenyl-1,2-benzisoselenazol-3(2H)-one (ebselen) derivatives, in search of increased in-vivo activity to combat oxidative stress and associated disorders, such as cardiovascular and Alzheimer’s diseases. Continuing her studies at Keele University, she is now undertaking a PhD within the group, concerning the design and chemical synthesis of sugar-nucleotide analogues.


Eleni Dimitriou
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Eleni was born in Nicosia, Cyprus and studied at the University of Cyprus where she was awarded a B.Sc. in Biological Chemistry (2014). Her final-year project was based on identifying new synthetic routes for producing 2-Amino-3H-phenoxazin-3-ones, designed for stabilising G-quadruplexes in DNA. Continuing her studies at University College London (UCL), Eleni obtained a MRes in drug design (2015), by undertaking a research project on investigating synthetic and structural approaches for probing SEMA3A and NRP1 interactions. Eleni joined the group in September 2016 as a Ph.D. student undertaking a project synthesising modified alginate oligosaccharides.

2nd Year

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Mieke Guinan

Mieke was born in Dublin, Ireland where she undertook a B.A. in Medicinal Chemistry in Trinity College, University of Dublin. Her research interests centre on the early drug discovery process, particularly synthetic medicinal chemistry. Her final year project involved the design of two families of analogous piperidine and piperazine guanidinium compounds as potential therapeutics against Mycobacterium tuberculosis, microbial assays of these compounds and subsequent analysis of the SAR. Mieke joined the group in September 2017 where she is focusing on a project involving the design and synthesis of nucleoside analogues to target viral diseases.

1st Year

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Caecilie Benckendorff

Caecilie is from Aarhus, Denmark. She moved to the UK in 2010, and began her studies at the University of Aberdeen in 2013, where she graduated in 2018 with a first class MChem degree. Her final year MChem project was undertaken at the University of Bergen, which involved the synthesis for ligands for riboswitches – a newly discovered novel target for antibiotics. During her project, she successfully synthesised the compound Ribocil C, and one analogue. Caecilie joined the group in September 2018, where her research focus on the design and synthesis of nucleoside analogues.




Group Alumni

Post-Doctoral

Dr Sanaz Ahmadipour
EPSRC funded PDRA (2016-2019) working on the design and synthesis of sugar-nucleotide analogues to target a strategic bacterial dehydrogenase. Now PDRA with Rob Field @ JIC.

MChem

2018

Mitchell Loach Chemical synthesis of a C6-homologue of mannose 1-phosphate. Now Engineer at T.E.S.T. Ltd

Hannah Wooton Chemical synthesis of a non-self alginate building block. Now Associate Scientist at Cyprotex.

2017

Katie Huxley Towards a chemical synthesis of phenyl-5-nitro-α-D-lyxopyranoside. Now PhD with Lianne Willems @ York.

2016

Jonathan Dolan Chemical Synthesis of GDP-D-ManA. Now PhD with Bruce Turnbull @ Leeds.

Jak Buxton:Synthesis of modified mannuronate building blocks. Now Chemical Engineer with Effectec.